Quercetin induces cytotoxicity and apoptosis, reduces metastasis and drug resistance in oral cancer cells

Abstract Quercetin is a plant flavonol from the flavonoid group of polyphenols or can also be formulated as synthetic supplement chemically. Approximately 80 % people in Africa and other developing nations still depend on traditional herbal remedies to treat ailments. has been demonstrated have variety anticancer effects. However, effect quercetin oral cancer cells remains rare. According our systematic review, includes anti-cell viability, survival proliferation. possesses an anti-metastatic by regulating expression epithelial-to-mesenchymal transition-related genes cells. The apoptotic probably via inducing cell surface death receptors, endoplasmic reticulum stress mitochondria-mediated signaling pathways. Additionally, reduces drug resistance KB/vincristine enhances sensitivity vincristine treatment. induces apoptosis human SAS through inhibits metastatic ability transition-mediated pathways squamous carcinoma. anti-tumour agent candidate inhibit tumour metastasis. Indeed, efficacy against chemically induced carcinoma elucidated.